Droplette Skin Nebulizer

Droplette Skin Nebulizer - Imagine Nespresso meets a nebulizer for local drug delivery. The Droplette is a handheld device that transforms treatment capsules into a high-speed micro-mist that penetrates the skin to a depth of ~ 20 cell layers. Without needles and pain, it achieves the depth of absorption of injectables, and its applications range from gene therapy to wound healing and cosmetic skin care. The Droplette is a physics-based device that converts serums with skincare ingredients into a powerful microflow, allowing them to penetrate deeply into the skin. What's the difference between a droplet? Not just another spray.
Of course, there are facial mists ... but the particles are large and slow, so the droplets accumulate on the skin, just making it wet. The droplet is fundamentally different. With two unexpected mechanical parts that deliver new physical strength, the Droplette is a tool that has been missing in your daily skincare routine.

The drip system consists of three parts that work together to give you the most of your daily skincare experience:

Device: Delivers ingredients deep into the skin through enhanced mist.

Capsules: contain compounds in daily doses. They are designed to be part of our daily life. Each capsule has a chip that contains composition information and syncs directly with the app so you can track what you use and when.

Application: allows you to communicate directly with an expert so that you can find the best daily routine for yourself; it also helps you keep track of the formulations you are using and your daily progress.

More than 90% of topical products (such as creams or serums) simply lie on the skin: the active ingredients are never absorbed into the skin. There are two reasons for this:
1. Our skin is designed to be a barrier, and its main function is to keep objects out, not let them in. In fact, there is a thick layer of skin called the stratum corneum, which is the densely packed collection of cell layers that make up the barrier. As a result, only small molecules (less than 500 daltons) can diffuse inside. Other molecules get stuck on the outside because they cannot physically be pushed inside. Many creams do have penetration enhancers that destroy the stratum corneum. and allow molecules to enter. But these are also often supplements that do no good to your skin and can often dry out or irritate it.

2. When you apply a cream or lotion to your skin, molecules can only get inside through diffusion. Diffusion is a slow process that is limited by the length that a molecule must travel. Even with penetration enhancers included in topical formulations, the actives are generally diffusion limited.

Meanwhile, spray-based skin care products do create a mist, but the drops that come out of this mist are large (sometimes up to 1-5 mm in diameter and at least 1000 times larger than our drops), and they do not have a sustainable source of acceleration. This means that when you spray on your face, all the drops merge together and eventually accumulate on your skin, leaving it moist.

Droplette is fundamentally different.
There are no penetration enhancers in our formulas, but we use two key ingredients inside our device to activate substances deeper in your skin.

The first is called a piezoelectric transducer or piezoelectric transducer. When we run electricity of a certain frequency through it, we can make the piezo vibrate. In our case, the piezoelectric element contains a steel mesh with very small holes (about 4 microns in size). When the piezo vibrates, liquids pass through this mesh and appear as a mist - similar to shaking a flour sieve: except in our case, the "shaking" is due to tension and "sifted flour" is a preparation that turns into an aerosol. The fog contains droplets the same size as the mesh, so when they come out of the piezo they are about 4 microns in diameter.

This mist that comes out of a single piezo still doesn't have the right droplet size or other fluid mechanic properties to support the deeper delivery that Droplette offers. That's why we've added a unique pump system: Our pump has three functions that no other skincare technology does:
1. The pump reduces the droplet size. It sucks in some of the mist and releases it at great speed. When this accelerated mist hits your skin, the droplets in it become even smaller. In fact, when hitting the skin, our droplets become about 30-50 times smaller than what comes out of a single piezo, due to the splashing effect. These smaller droplets also are fast moving and have acceleration, which means they can wade through the skin.

2. The pump disperses the fog: you will feel the air flow, even if no fog comes out of the device; when there is fog, the air flow accelerates the droplets, turning them into a high-speed jet to better penetrate the skin. In addition, convection from this air stream can evaporate water from droplets on the skin, but does not evaporate active molecules. Instead, the drops become more concentrated on the skin - and the more concentrated the drops are, the more efficient the diffusion will be. This can be understood by thinking of something as simple as cooking something on the stove. If you add a high concentration of spices, the smell will spread through the kitchen much faster than if it were heavily diluted.

3. The air flow of the pump also serves to damage your skin a little - just enough to improve the delivery of molecules. This is a temporary effect (on the order of microseconds) and does not cause long-term damage to the skin, but it helps to transport the molecules deeper into the skin.

Droplette not only provides more active substances, but also has a super-hydrating effect.
One of the special aspects of Droplette is that because our formulas are completely water based with minimal preservatives, we can deliver much more of this water to your skin using our technology. Thus, in addition to the fact that the active substances can penetrate deeper, we deliver about 50% more water than would be delivered locally, and this water also stays there longer. This allows you to use active ingredients that might otherwise dry out or irritate your skin without experiencing the side effects you would normally experience.

How does it look like?
Method: injecting 50 µl of distilled water into the arm area continuously for 30 seconds using drops against 100 µl of distilled water when applied topically. Both areas (drops against topical areas) were blotted dry 5 seconds after administration. Hydration was assessed by visual inspection and a Corneometer CM825.

Results. No discoloration or discomfort was reported in any of the groups after 24 hours. Hydration increased by an average of 58.7% with the introduction of water by means of drops compared to only 22.8% in the control group (topical water).

None of the subjects reported any unpleasant side effects within 24 hours and described the Droplette spray as a slightly cool mist sensation.